The Wildcats finished 12 shots behind Marshall County, who won the tournament on their home course with a 21-over-par score of 309.
The Marshals were four shots better than St. Mary and seven better than Paducah Tilghman, who saw their streak of four straight region titles end with a third place finish.
Heath (318) was fourth, and Trigg County tied Lone Oak (321) for fifth.
Not qualifying for the state meet was especially discouraging since the Wildcats didn’t lose a dual match until the final week of the season and finished second at two major invitationals during the season.
Bradley Sutherland was Trigg’s top golfer with a 5-over 77, good for a ninth place tie.
Sutherland missed a playoff by one shot to determine the final individual qualifier, joining defending region champ Chris Griffin of Tilghman who also failed to advance.
Curtis Mitchell shot an 8-over 80 for the Wildcats, followed by Jordan McNichols and Taylor Lowary, who each carded an 82, and Tyler Mitchell who shot an 84.
St. Mary freshman Case Cochran, son of PGA golfer Russ Cochran, edged his cousin Rick Cochran of Heath by one shot to win the region title and become the third member of his family to win the region tournament.
Cochran shot a 1-over 73.